3 ms·

I wonder how widespread Lyme Disease has to get before the economic incentives to develop a new vaccine reach a tipping point. There used to be a vaccine but i

I wonder how widespread Lyme Disease has to get before the economic incentives to develop a new vaccine reach a tipping point. There used to be a vaccine but it was discontinued because of insufficient demand. https://www.niaid.nih.gov/diseases-conditions/lyme-disease-vaccines https://www.niaid.nih.gov/diseases-conditions/lyme-disease-v... "In April 2002, GSK announced that even with the incidence of Lyme disease continuing to rise, sales for LYMErix declined from about 1.5 million doses in 1999 to a projected 10,000 doses in 2002." How do we square this with the number of cases rising so much over the last few years?

Glyptodon 9y ago
http://www.newsweek.com/lyme-disease-vaccine-valneva-fda-approva-641796 http://www.newsweek.com/lyme-disease-vaccine-valneva-fda-app...
seren 9y ago
Strangely enough you can get your dog vaccinated but not yourself. >As of December 2016, a Phase I clinical trial was announced for a new candidate vaccine developed by the French company Valneva. The vaccine is similar to the SmithKlineBeecham product, but the vaccine is multivalent, targeting six Borrelia OspA serotypes. The trial will test vaccine safety, and a later Phase II trial will test efficacy.[xi] Baxter, an Austrian company, had previously tested another vaccine candidate in a combined Phase I/II trial, but the company seems to have abandoned development.[xii] http://www.valneva.com/en/rd/vla15 http://www.valneva.com/en/rd/vla15
- ams6110 9y ago
  Safety standards for animals are lower.
  - pvaldes 9y ago
    And higher risk to play outdoors all the time unprotected, and different methabolism.
  - mrfusion 9y ago
    Does the fda have jurisdiction over animal drugs? I’m surprised they’d do an official clinical trial.
    - refurb 9y ago
      Yes, the FDA approves animal drugs as well.
raesene9 9y ago
LYMErix suffered from actual or imagined side-effects that led to lawsuits, which were a factor in GSK discontinuing it. From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/ "Spawned by the press coverage of vaccine risks and the ongoing litigation, vaccine sales fell off dramatically in 2001. " there's at least one new vaccine in development http://www.valneva.com/en/rd/vla15 http://www.valneva.com/en/rd/vla15
- jobu 9y ago
  Aside from the rare negative effects, the major issues with it were the efficacy of around 80% and that it interfered with Lyme tests. (All of the people that took the vaccine test positive for Lyme Disease.) This uncertainty made it challenging to know the cause of future illness.
  - mobilefriendly 9y ago
    And only 80% effective means you still need to take all precautions like DEET and such.
billman 9y ago
I took the first two doses of LYMErix and started to get knee pain. I wasn't the only one. I'm pretty sure the reason they took it off the market is because is was causing issues.
eip 9y ago
The government spent a lot of money to develop the Lyme bio-weapon (and probably also a vaccine). I doubt they would be super excited about a vaccine being made available to the public.

Glyptodon 9y ago

http://www.newsweek.com/lyme-disease-vaccine-valneva-fda-approva-641796 http://www.newsweek.com/lyme-disease-vaccine-valneva-fda-app...

seren 9y ago

Strangely enough you can get your dog vaccinated but not yourself. >As of December 2016, a Phase I clinical trial was announced for a new candidate vaccine developed by the French company Valneva. The vaccine is similar to the SmithKlineBeecham product, but the vaccine is multivalent, targeting six Borrelia OspA serotypes. The trial will test vaccine safety, and a later Phase II trial will test efficacy.[xi] Baxter, an Austrian company, had previously tested another vaccine candidate in a combined Phase I/II trial, but the company seems to have abandoned development.[xii] http://www.valneva.com/en/rd/vla15 http://www.valneva.com/en/rd/vla15

ams6110 9y ago
Safety standards for animals are lower.
- pvaldes 9y ago
  And higher risk to play outdoors all the time unprotected, and different methabolism.
- mrfusion 9y ago
  Does the fda have jurisdiction over animal drugs? I’m surprised they’d do an official clinical trial.
  - refurb 9y ago
    Yes, the FDA approves animal drugs as well.

raesene9 9y ago

LYMErix suffered from actual or imagined side-effects that led to lawsuits, which were a factor in GSK discontinuing it. From https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/ "Spawned by the press coverage of vaccine risks and the ongoing litigation, vaccine sales fell off dramatically in 2001. " there's at least one new vaccine in development http://www.valneva.com/en/rd/vla15 http://www.valneva.com/en/rd/vla15

jobu 9y ago
Aside from the rare negative effects, the major issues with it were the efficacy of around 80% and that it interfered with Lyme tests. (All of the people that took the vaccine test positive for Lyme Disease.) This uncertainty made it challenging to know the cause of future illness.
- mobilefriendly 9y ago
  And only 80% effective means you still need to take all precautions like DEET and such.

billman 9y ago

I took the first two doses of LYMErix and started to get knee pain. I wasn't the only one. I'm pretty sure the reason they took it off the market is because is was causing issues.

eip 9y ago

The government spent a lot of money to develop the Lyme bio-weapon (and probably also a vaccine). I doubt they would be super excited about a vaccine being made available to the public.