With Python3 and PyQt5 it is literally as simple as "pip install pyqt5". I speak from having built and maintained multiple PyQt-based apps on MacOS. Edit: I sh

With Python3 and PyQt5 it is literally as simple as "pip install pyqt5". I speak from having built and maintained multiple PyQt-based apps on MacOS. Edit: I should say, there are MacOS-unique difficulties if you want to bundle your nice PyQt5 script into a standalone MacOS app bundle using PyInstaller. But that's a separate issue.