In the visual effects industry, it's common practice to write GUIs using Python and Qt that are compatible with PySide, PySide, PyQt4 and PyQt5 all at once. I t

In the visual effects industry, it's common practice to write GUIs using Python and Qt that are compatible with PySide, PySide, PyQt4 and PyQt5 all at once. I think that speaks for how similar these bindings really are. Source: I maintain the most widely used shim for such occasions https://github.com/mottosso/Qt.py https://github.com/mottosso/Qt.py