3 ms·
That doesn't interfere with any other part of the genome... That's a hard compute problem.
by toufka 8y ago
That doesn't interfere with any other part of the genome... That's a hard compute problem.
- biridir 8y agoDo you mean the effect of the actual gene knockout, crispr specificity or off-spot mutations?
- klmr 8y agoCRISPR specificity. Designing good gRNAs isn’t quite trivial, although it’s not as hard as the article makes it seem. I’m not sure about the claim of reducing the time of experiments by “month”.
- biridir 8y agohttp://crispr.mit.edu/about http://crispr.mit.edu/about Designing a good gRNA is quite straightforward if you compare it to any other bioinformatics tasks. Even designing a degenerate primer is more complex than this.