Given design rules covering trucks being driven on highways, yes. Start with a bumper as per regulations. It has to be the furthest forward part of the vehicle

Given design rules covering trucks being driven on highways, yes. Start with a bumper as per regulations. It has to be the furthest forward part of the vehicle, close to ground level. No pointy aircraft noses on road transport. Now shape the hulk to sweep air aside in clean smooth lines to sufficient height and width to clear standard sized trailers. The design goal coefficient dictates how smooth the surface has to be, and the curvature of that surface. What is left for the designer is flourishes like the profile of the windscreen, how many wipers there are, how they are concealed, and the shape of the door and whether the door opens to the front or the rear.