There were hand-coded assembly loops that were 3-4 times faster than x86, using Itanium's predicates and rolling register windows. But I guess you said mainstr

There were hand-coded assembly loops that were 3-4 times faster than x86, using Itanium's predicates and rolling register windows. But I guess you said mainstream. So unless you count database engines, I suppose the answer is "No." Today you can get the same vector performance using SSE4 and AVX. Almost all of Itanium's good stuff has been rolled into Xeon.