No, I think it’s totally possible (albeit exceedingly unlikely). But we already know that CRISPR has (rare) off-target effects. That’s why I’m saying that the i

No, I think it’s totally possible (albeit exceedingly unlikely). But we already know that CRISPR has (rare) off-target effects. That’s why I’m saying that the i-motifs don’t change the risk assessment. At best, they can explain why CRISPR sometimes misbehaves (although it’s much more likely due to just plain old nonspecific binding in most cases).