Running VMs for testing during development (ie: an IE6 VM, IE7 VM, etc) are the major driver for us. Outside of that, my work machine has Chrome, Mail.app, Ter

Running VMs for testing during development (ie: an IE6 VM, IE7 VM, etc) are the major driver for us. Outside of that, my work machine has Chrome, Mail.app, Terminal and Textmate open generally so 2GB is fine without the VMs. My home machine is the previous generation, top of the line iMac (3GHz, 2GB) and is often noticeably sluggish. It looks like iTunes is responsible for a bit under 200MB. I really don't know what the issue is though to be honest, but it feels like a 4GB upgrade would get it over the hump.