Yes, have been doing so since about Fedora 10, with about 30 VMs used for various purposes (i.e. it's not just a cluster of 30 identical systems). Version upgr

Yes, have been doing so since about Fedora 10, with about 30 VMs used for various purposes (i.e. it's not just a cluster of 30 identical systems). Version upgrades in the early days weren't great, but recently (last 5 years or so) it's been totally fine. Prior to that I used to do LTS-style distros, with version upgrades every 2 or 3 years, but I've found that testing the impact of an upgrade is far easier if you're doing incremental changes every 6-12 months.