The context is that Buckley was criticized for shallow comics, so he dropped Loss.jpg as a bomb on his detractors, who turned it into a meme. From the article:

The context is that Buckley was criticized for shallow comics, so he dropped Loss.jpg as a bomb on his detractors, who turned it into a meme. From the article: > The last strip to mention Lilah’s pregnancy prior to “Loss” had been published 10 installments and nearly a month prior, and readers found the sudden attempt at gravity hilarious. So they did what the internet does: turned “Loss” — again, a comic strip about miscarriage — into a running joke