4 ms·
Yeah, I would hope that we find more durable solutions. I know some people have been on it for an extended interval without any sort of tolerance problem, whic
by rincebrain 9y ago
Yeah, I would hope that we find more durable solutions.
I know some people have been on it for an extended interval without any sort of tolerance problem, which is how I initially heard about it firsthand, so it's one more of those strange biochemistry things that's inconsistent, because of course it is.
The interesting thing, to me, would be figuring out what the method of action is for the effect, in order to replicate it in other drugs, but we'll see.
(I'm also curious whether repeating the dense dosages would be effective again for me now, over a year later, or whether the tolerance would be, indeed, permanent.)
- sibeliuss 9y agoI'm curious about whether you've tried to push the dosages into more psychedelic ranges and whether that had an effect? Many researchers seem to think that at sub-dissociative levels the effectiveness is less, as the _experience_ of that state is what alleviates the depression, not the chemical (so to speak).
- rincebrain 9y agoMost sub-dissociative levels were probably with nasal sprays; I can assure you, this was definitely dissociative levels every time, via IV. We tried increasing the dosage, which made the dissociation more potent, but had no improved psychiatric benefits for me.