3 ms·
One should note that this would have happened >10 years ago if we hadn't gotten the lucky stroke of the century. After 40 years of zero active antibiotic discov
by candiodari 9y ago
One should note that this would have happened >10 years ago if we hadn't gotten the lucky stroke of the century. After 40 years of zero active antibiotic discoveries we found a few new types. Currently, they work.
The previous types lasted 60 years. The new set lasted ~6 years, or 10 years if you count until we found diseases resistant to both the new and all old types. They're resistant, so the antibiotics still help, but they only slow it down, they don't actually cure anymore. We probably have months until they're fully immune all types.
The issue is that bacteria regularly exchange genes outside of their particular species, so given historical data we have ~2 years time before there are outbreaks of every known disease which fully ignore all types of antibiotics.
This means that (assuming it is verified, and if it isn't, some other outbreak will be verified soon) at this point it is utterly too late for any attempt at restricting antibiotics (which governments are only doing to save money anyway, which is why it is only restricted for human patients and not or very little for agriculture. Besides, it doesn't matter unless every government does it). Worse: at this point restricting antibiotics is counterproductive: we should immediately switch to a different regimen, to maximize the remaining utility. When a patient gets infected with an unknown disease, and there's even slight reasons to suspect resistant strains, they should immediately get a cocktail. A high dose of the 5 known general antibiotics. Especially children.
We all know it won't be done. Firstly, governments move slowly, and never admit mistakes or failure (although you have to appreciate just how slow: outpaced by evolution. I mean ... seriously ?). Admitting failure will be the bigger problem no doubt.
Secondly, it is slightly expensive. It will save many lives, maximize the remaining utility and prevent outbreaks, but it will be somewhat more expensive.
Result will, inevitably, be that in 2 years, half a dozen (common) diseases will require extremely expensive "long-tail" medicines. In a decade, every disease will require it. We need to get started on developing hundreds, and then thousands of individual medications, requiring much more money for medical research than is currently being spent.
And we all know we won't do that. First victim will be sex. Why ? Because when a disease gets called "sexually transmitted" that mostly means only sexually transmitted (the only more restrictive form is blood-transmitted. Only gets transmitted from mother to child or through blood transfusions). Sex will transmit pretty much every disease known with only a few exceptions. When we have 5 common incurable diseases, sex with many partners becomes Russian roulette. When we have 50 ...
- tzahola 9y agoWhat about bacteriophages?
- candiodari 9y agoThose are viruses, and as a rule there are no generic drugs that directly act against large classes of viruses. In most cases, with viral infection symptomatic treatment is the only option available.
- cfadvan 9y agoI think they’re asking if bacteriophage therapy could replace antibiotic therapy? The answer is no, because you require a specific phage to treat a specific bacterial species, and since phases don’t tend to naturally infect us, it’s hard to get the phases to where the bacteria are. Phage therapy can work for something like strep throat, when you can literally rinse your throat with a solution containing phases, but basically useless for something like bone or blood infections.
- tzahola 9y agoHow about an IV phage cocktail? https://www.ncbi.nlm.nih.gov/m/pubmed/26691737/ https://www.ncbi.nlm.nih.gov/m/pubmed/26691737/
- dayofthedaleks 9y agoI know it's some ways off, but I like to think we eventually will be able to create bespoke bacteriophages via genemods, tailored both to the patient's genome profile and the infection at hand. All the exciting cancer stuff right now seems to be on-demand, and techniques spread over time.
- Luc 9y agoThe idea is to use them instead of antibiotics. Phage therapy.
- StavrosK 9y ago