Okay, no. Stop a second. To use an analogy that HN might understand, doing that would be like using those giant javascript frameworks to create a distributed,

Okay, no. Stop a second. To use an analogy that HN might understand, doing that would be like using those giant javascript frameworks to create a distributed, dynamic website to serve a couple lines of static text. The answer is blotting. You do Southerns and Northerns and you'll see exactly whether or not you have off-targets. This is super basic stuff, and very reliable.