Personally I went off SSRIs because from the start I chose to look at them as a tool. I had no symptoms of depression until my mid 20s so I didn't buy the metap

Personally I went off SSRIs because from the start I chose to look at them as a tool. I had no symptoms of depression until my mid 20s so I didn't buy the metaphor that SSRIs were filling some inborn defect in my brain. I got stuck in a rut of bad thinking patterns which I re-framed through therapy and SSRIs. I don't think going off them had to do with worries over "unnatural" , rather it was just human curiosity to understand my own brain. I've tried other illegal drugs for similar cognitive insights. It just so happens that SSRIs are legal and have some degree of clinical efficacy. As a side note I think therapy did more for me than SSRIs and I'm still in therapy but ymmv. Finding a good therapist is way harder than finding an anti-depressant prescription.