Take Crohn's for example. Sure you can be on Remicade for a decade with no significant flare-ups. Then the day Remicade stops being effective you're completely

Take Crohn's for example. Sure you can be on Remicade for a decade with no significant flare-ups. Then the day Remicade stops being effective you're completely screwed. Plus your situation got worse over time, you just didn't get the messages your body has been trying to send you. Remicade was essentially the firewall.