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You can label receptors with aptamers and other technology, and then sequence the aptamer labels (or whatever). Many in situ sequencing techniques can be applie
by kanzure 9y ago
You can label receptors with aptamers and other technology, and then sequence the aptamer labels (or whatever). Many in situ sequencing techniques can be applied here. Note, however, that this requires more steps than simply scanning with electron microscope multi-array.
- mrfusion 9y agoInteresting. Maybe also doing some kind of rnaseq synapse by synapse could tell you what levels of neurotransmitters and receptors it’s maintaining. I’m not sure if that small of a scale would ever be possible.
- kanzure 9y agoYeah, it would certainly help to use a method like expansion microscopy, sort of like if Nectome were to subcontract some work to a certain MIT lab that invented the techni--- oh wait..