I've used cherrypy + mako in a few projects (https://github.com/kakwa/dnscherry https://github.com/kakwa/dnscherry and https://github.com/kakwa/ldapcherry https

I've used cherrypy + mako in a few projects (https://github.com/kakwa/dnscherry https://github.com/kakwa/dnscherry and https://github.com/kakwa/ldapcherry https://github.com/kakwa/ldapcherry). It's quite easy to pick-up and does the job very well. It supports running directly over http, but you can also run it in wsgi or fastcgi modes without issues. And it's also quite stable in term of APIs, my projects are now 4 years old, and I didn't have any breaking changes in their API. It makes it quite easy to support various distributions and version without kludges in the code to handle different versions or having to bundle cherrypy with the application. Even my monkey patches of the framework (slight change in the configuration parser) are not breaking ^^.