3 ms·
"We are not able to make any definitive claims that this compound is safe..." Is this quote taken out of context? Because I thought the first step of any sort
by epmaybe 9y ago
"We are not able to make any definitive claims that this compound is safe..."
Is this quote taken out of context? Because I thought the first step of any sort of human trial of a drug is to determine its safety. Intuitively I can't see how NR would be any different safety-wise than niacin (vitamin b3), but more clarification would be nice. Anyone who has read the paper willing to chime in?
- marshray 9y agoIt's fundamentally the responsibility of the FDA to regulate "definitive claims that a compound is safe", whereas the standard for approval for use in a clinical trial is a bit different.
- toufka 9y agoAnd this is a general issue with prophylactic or anti-aging style 'drugs'. Demonstrating a compound is safe enough to not cause undue harm while helping to rid the body of an accute ailment is a very different kind of 'safe' than something one might be expected to take every day for years.
- mkempe 9y agoWhat they mean is that they are not allowed by the FDA to make any such claims.
- SCAQTony 9y agoWell, it is in cow milk: https://www.ncbi.nlm.nih.gov/pubmed/27052539 https://www.ncbi.nlm.nih.gov/pubmed/27052539
- berdon 9y agoTangentially related to the safety of niacin, for most people niacin/B3 is relatively inert and used by the body. In fact, if you don't get enough of it, you fall in danger of having pellagra [1]. If I eat it, I'm guaranteed to get an ocular (ophthalmic) migraine. [1] https://en.wikipedia.org/wiki/Pellagra https://en.wikipedia.org/wiki/Pellagra