Talk about the weather, talk about current events, talk about video games, normal stuff..? People don't want to be reminded of the curse they've been afflicted

Talk about the weather, talk about current events, talk about video games, normal stuff..? People don't want to be reminded of the curse they've been afflicted with, especially if it isn't going to help change it. This goes for anyone who has a handicap. The handicap is always on a scale of 1 to 10 where at 1, it doesn't define the person, and at 10, their whole lifestyle is constrained. But nomatter what, no one on that scale wants to be reminded of a curse that is so vicious it affects so much of their life. Treat them as a person first, and maybe if you get to know them, then you can ask about the affliction.