I empathize. Had major trouble myself with the same. This is a run down of everything I tried to some positive effect: * Hand, forearm, shoulder and neck massa

I empathize. Had major trouble myself with the same. This is a run down of everything I tried to some positive effect: * Hand, forearm, shoulder and neck massage. Weekly if need be. Don't discount problems in your shoulders causing issues in your wrists. * Stopped using a single hand mouse, learned keyboard shortcuts. My RSI was worse on my mouse hand. The constant moving right hand off keyboard at 12 o'clock to 1 o'clock to click with mouse was a killer. Keeping hands centered and relatively immobile over keyboard helped. * Bought my own office chair that fit me. I am short through the torso and chairs could never lift me high enough for me to avoid lifting elbows. * Bought an ergonomic keyboard and mouse. * Bought an ergonomic keyboard augment (kind of a tray that the keyboard sat upon, that had padded extensions under either side of my wrists) that kept my wrists off the edge of desk, edge of laptop, etc.) * Every job I got, I brought my own chair and equipment and tossed whatever my employer provided. * I had an ergonomics consultant come in and check my posture, desk, and chair set up. As a heavy traveler, I'd really try the massage because you can get a massage in lots of locations. My shoulders were a great part of the problem. Good luck. Edit: I think I should also explain some of the difficulties I had with employers. Occasionally I got crap because I created an extra chair by bringing my own. I explained that I spent more time in my office chair than I did in my own bed, and I didn't purchase my bed by finding the cheapest mattress. Since I was in my chair more than my bed, I had even higher expectation of fit and comfort. If they had a problem with my asset being on their premise, they were free to buy the chair from me at my cost. Please see copies of medical bills which I'd be happy to claim as an expense. The other issue I had was with IT. They would see all the nonstandard equipment and then say "we can't support X because of specialized keyboard or mouse". My response would be "I completely understand the needs of IT for support-ability. Please see copies of my medical bills for RSI and massage treatment. Please have IT procurement buy replacement equipment under IT's procurement control to ensure support-ability." Both of these strategies proved successful with employers and the IT staff.