If you want end-to-end Clojure/Lisp while retaining access to large ecosystems there's Clojurescript for the browser and Node.js, Hy (http://hylang.org http://h

If you want end-to-end Clojure/Lisp while retaining access to large ecosystems there's Clojurescript for the browser and Node.js, Hy (http://hylang.org http://hylang.org) for scripting and data science plus Clojure for JVM/large applications with performance. Now you can get a VPS with 4Gb of RAM for £5/month at Hetzner (http://hetzner.com http://hetzner.com) so JVM memory usage is no longer an issue. These are exciting times indeed for developers.