Nice. I assumed NGF interactions with other developmental signalers like SHH, BMP, etc was the mechanism of action in this anyways. It's been a while since I w

Nice. I assumed NGF interactions with other developmental signalers like SHH, BMP, etc was the mechanism of action in this anyways. It's been a while since I was in a devo lab, but I've watched a few presentations regarding wound healing and denervation such as seen in paraplegics with sacral ulcers. The hypothesis was that the nerves were gone and therefore NGF and other trophic factors were gone leading to impaired healing. I'm assuming healing and development are nearly synonymous in some tissues. Like you said, it's not the electrical signals that necessarily matter that much, it's the chemicals produced by the nerves.