With web assembly you don't have to write a lick of javascript to write a guide in some other language that uses a completely accessible dom tree under the hood

With web assembly you don't have to write a lick of javascript to write a guide in some other language that uses a completely accessible dom tree under the hood, provided your library provides the glue (like the rust library Yew). There's no reason one couldn't wrote a UI frame work like the ones mentioned by the parent that use the dom under the covers.