4 ms·
It has started to come up a lot recently in order to produce the above-like click-bait headlines. Here's my standard copy-pasta quoting myself from when it sho
by toufka 9y ago
It has started to come up a lot recently in order to produce the above-like click-bait headlines. Here's my standard copy-pasta quoting myself from when it shows up around here:
Epigenetics. It's the make-file for your genetic source code. Certain conditions can cause certain parts of your genetic code to be uncommented or commented-out within any given cell or set of cells. There are actually a number of different kinds of 'comments' (histone modifications [1]) - each set of marks are particular to a different compiler, in different contexts. And these comments/marks are copied with some fidelity to daughter-cells/children along with a high-fidelty copy of the underlying genetic code itself.
So the genes (DNA) themselves are not being heritably altered, rather the recipe for which gene is produced, when, and where can be subtly changed. But again, the same mechanisms that permit the change in expression of those genes during a lifetime (of an organism, or a cell) can be subsequently changed in the next just as easily.
In this way you can store the code for some trait or capability over many generations without having it always be running. It can manifest itself in individual organisms or cells as having very different phenotypes even while possessing the same underlying genetic code.
[1] https://en.wikipedia.org/wiki/Histone_code https://en.wikipedia.org/wiki/Histone_code
- tmsldd 9y agoThanks for the analogy, I’m actually copying & pasting for future references ;)
- Retric 9y agoIt's arguably much closer to RAM than a make file. Picture a Glucose detector wrapped around a DNA segment that encodes something to break down Glucose. If you zero Glucose inside the nucleus you stop producing stuff to deal with it. The difference for this analogy is cells never stop compiling. On the other hand if you think of cell division as a reboot it's a better fit.
- fnl 9y agoYour epigenetic state very much starts off inherited from your parents. Also, it's not just a gene switch, and in fact that probably is it's least relevant role, if any. Rather, and besides being a hereditary factor, it determines the structure/packing of your nucleosomes, and therefore determines the integrity of your cell as a whole, not just your gene expression levels.