In addition to lacking wheat pre-agriculture there's a reasonable amount of evidence that the modern increase is due to the elimination of gut parasites - previ

In addition to lacking wheat pre-agriculture there's a reasonable amount of evidence that the modern increase is due to the elimination of gut parasites - previously the increased immune activity in the gut was beneficial (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403024/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403024/). There's also some research that suggests modern high-gluten wheat varieties have more of the proteins that trigger coeliac disease (https://www.nature.com/articles/srep44609 https://www.nature.com/articles/srep44609)