It seems to me that with the lack of resources, and inability to separate out cause and effect of many foods that effect our biology, the rational reaction is t

It seems to me that with the lack of resources, and inability to separate out cause and effect of many foods that effect our biology, the rational reaction is to adopt a sort of cargo cult mentality. If we really have no idea whether sucralose is good or bad for us over a long period (or which conditions it even could be good or bad for us), if you want to maximize your healthy outcomes you just avoid it. Its pretty incredible to me just how little we really know about optimizing diets except in extreme situations.