Looks like there's a known effect where quinine alters the binding capabilities of antibodies, giving the antibodies affinities to substrates that they would no

Looks like there's a known effect where quinine alters the binding capabilities of antibodies, giving the antibodies affinities to substrates that they would not otherwise bind to [1]. https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=4626254_2138f5.jpg https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/t... Curious. Wonder what about quinine makes it a relatively common component of a synthetic paratope. [1] https://www.ncbi.nlm.nih.gov/pubmed/26282540 https://www.ncbi.nlm.nih.gov/pubmed/26282540 [edit] It looks like quinine binds heme to some extent [2] (as do most anti-malarial drugs). And that this binding somehow prevents parasites from properly digesting the hemoglobin protein. So if quinine binds heme molecules, and an antibody in your body has an accidental affinity for the quinine-bound-heme structure, the chances for an immune response seem high. [2] https://www.sciencedirect.com/science/article/pii/S1044030504002879 https://www.sciencedirect.com/science/article/pii/S104403050...