5 ms·

FWIW, here's an anecdote from someone with an auto-immune disorder. I've had MS (multiple sclerosis) for 20 years. In that time, I've lived in 7 different clima

FWIW, here's an anecdote from someone with an auto-immune disorder. I've had MS (multiple sclerosis) for 20 years. In that time, I've lived in 7 different climates for a year or longer each. I didn't get my first symptoms until I moved to northern Europe during the winter. The times that I've had no disease progression, I was closer to the equator. For example, I had no issues at all in the 5 years I lived in central Texas. The times I've had disease progression, I've been further north (above the 37th parallel). Since I'm currently living in the 47th parallel, I take 10,000 I.U. of Vitamin D a day. The one time I've had a serious increase in disease activity while living here, I tried taking a year off the Vitamin D supplements because I thought my medication was sufficient.

trhway 9y ago
googling myelin and vitamin D does bring a bunch of info in that direction, for example : https://www.ncbi.nlm.nih.gov/pubmed/27764518 https://www.ncbi.nlm.nih.gov/pubmed/27764518 "In the central nervous system (CNS) the main proteins of myelin are proteolipid protein (PLP), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and CNPase. [...] The mice were treated by cuprizone for five weeks in order to induce demyelination. [...] a significant increase in the MOG and CNPase expression was seen in vitamin D injected group as compared to SHAM and control groups. It is concluded that vitamin D plays a role in the process of remyelination by increasing MOG and CNPase expression in the cortex."