There is a bit of very recent, new epigenetics controversy in this preprint: https://www.biorxiv.org/content/early/2017/09/20/170506 https://www.biorxiv.org/con

There is a bit of very recent, new epigenetics controversy in this preprint: https://www.biorxiv.org/content/early/2017/09/20/170506 https://www.biorxiv.org/content/early/2017/09/20/170506 >Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulation tl;dr: they engineered a protein which methylates regions of the genome in human cells and checked how that affects gene transcription. In many cases where they showed that the gene's regulatory region was methylated were still transcribed, contrary to what many other studies are indicating. >These findings suggest that promoter DNA methylation is not generally sufficient for transcriptional inactivation, with implications for the emerging field of epigenome engineering. Perhaps methylation could be a footprint of something we don't know about yet.