4 ms·

Defect rates have long been overstated. https://mobile.nytimes.com/2002/04/04/us/few-risks-seen-to-the-children-of-1st-cousins.html https://mobile.nytimes.com/

Defect rates have long been overstated. https://mobile.nytimes.com/2002/04/04/us/few-risks-seen-to-the-children-of-1st-cousins.html https://mobile.nytimes.com/2002/04/04/us/few-risks-seen-to-t...

walrus01 9y ago
google "endogamous population genetic disorders" - I could easily paste a dozen more citations here... https://www.sciencedirect.com/science/article/pii/S1110863017300174 https://www.sciencedirect.com/science/article/pii/S111086301... "Conclusion The present study revealed a higher incidence of certain diseases in consanguineous population with a high significant increase in the prevalence of common adult diseases such as diabetes mellitus, cancer, blood disorders, mental disorders, heart diseases, asthma, gastro-intestinal disorders, hypertension, hearing deficit, G6PD and common eye diseases. This confirms the role of genetic factors across the full spectrum of disease and not only for Mendelian disorders." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666836/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666836/ A positive correlation between inbreeding and numerous health outcomes has been reported in several studies. Indeed, unions between relatives are generally associated with an increased risk of abortions, stillbirths (Al-Awadi et al. 1986; Hussain 1998, 1999; Hussain et al. 2001), perinatal mortality (Stoltenberg et al. 1999), and congenital malformations (Abdulrazzaq et al. 1997; Chéhab et al. 2006; Yunis et al. 2006). Consanguineous marriages are also recognized as being associated with higher risk for autosomal recessive diseases than in the general population (Taillemite et al. 1985; Alwan and Modell 1997; Kumaramanickavel et al. 2002) by favoring the expression of recessive deleterious alleles. Many reports have highlighted a positive association between inbreeding and a number of recessive single gene disorders like achromatopsia (Tchen et al. 1977), Leber's congenital amaurosis, xeroderma pigmentosum (Mokhtar et al. 1998), and metabolic defects like aminoacidopathies and mucopolysaccharidoses (Jaouad et al. 2009). However, some authors believe that a long practice of inbreeding over several generations leads to the elimination of deleterious recessive mutations from the population gene pool (Khoury et al. 1987).
- chapill 9y ago
  You're not addressing the point of the NYT article I posted: 'In terms of general risks in life it's not very high,' Dr. Motulsky said. Even at its worst, 7 percent, he said, '93 percent of the time, nothing is going to happen.' Is there a statistically significant difference in defect rates? Yes. Is it a very large difference? None of your reply addresses that point. The doctor in the NYT article says no.
Gatsky 9y ago
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196914/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196914/
Gatsky 9y ago
The excess risk of defects etc is about 2%. That's a lot! That is many thousands of kids that are suffering unnecessarily. If the governments in cousin marriage permissive countries actually had to pay the cost of looking after these disabled people, cousin marriage would be out the door very quickly. There was also a study looking at the genomes of a large consanguineous pedigree. The amount of pathogenic genome changes seen was shocking, amazing that the phenotypes were normal or mild... that is a gift you will pass on to all your descendants.

Defect rates have long been overstated. https://mobile.nytimes.com/2002/04/04/us/few-risks-seen-to-the-children-of-1st-cousins.html https://mobile.nytimes.com/2002/04/04/us/few-risks-seen-to-t...

walrus01 9y ago

google "endogamous population genetic disorders" - I could easily paste a dozen more citations here... https://www.sciencedirect.com/science/article/pii/S1110863017300174 https://www.sciencedirect.com/science/article/pii/S111086301... "Conclusion The present study revealed a higher incidence of certain diseases in consanguineous population with a high significant increase in the prevalence of common adult diseases such as diabetes mellitus, cancer, blood disorders, mental disorders, heart diseases, asthma, gastro-intestinal disorders, hypertension, hearing deficit, G6PD and common eye diseases. This confirms the role of genetic factors across the full spectrum of disease and not only for Mendelian disorders." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666836/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666836/ A positive correlation between inbreeding and numerous health outcomes has been reported in several studies. Indeed, unions between relatives are generally associated with an increased risk of abortions, stillbirths (Al-Awadi et al. 1986; Hussain 1998, 1999; Hussain et al. 2001), perinatal mortality (Stoltenberg et al. 1999), and congenital malformations (Abdulrazzaq et al. 1997; Chéhab et al. 2006; Yunis et al. 2006). Consanguineous marriages are also recognized as being associated with higher risk for autosomal recessive diseases than in the general population (Taillemite et al. 1985; Alwan and Modell 1997; Kumaramanickavel et al. 2002) by favoring the expression of recessive deleterious alleles. Many reports have highlighted a positive association between inbreeding and a number of recessive single gene disorders like achromatopsia (Tchen et al. 1977), Leber's congenital amaurosis, xeroderma pigmentosum (Mokhtar et al. 1998), and metabolic defects like aminoacidopathies and mucopolysaccharidoses (Jaouad et al. 2009). However, some authors believe that a long practice of inbreeding over several generations leads to the elimination of deleterious recessive mutations from the population gene pool (Khoury et al. 1987).

chapill 9y ago
You're not addressing the point of the NYT article I posted: 'In terms of general risks in life it's not very high,' Dr. Motulsky said. Even at its worst, 7 percent, he said, '93 percent of the time, nothing is going to happen.' Is there a statistically significant difference in defect rates? Yes. Is it a very large difference? None of your reply addresses that point. The doctor in the NYT article says no.

Gatsky 9y ago

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196914/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196914/

Gatsky 9y ago

The excess risk of defects etc is about 2%. That's a lot! That is many thousands of kids that are suffering unnecessarily. If the governments in cousin marriage permissive countries actually had to pay the cost of looking after these disabled people, cousin marriage would be out the door very quickly. There was also a study looking at the genomes of a large consanguineous pedigree. The amount of pathogenic genome changes seen was shocking, amazing that the phenotypes were normal or mild... that is a gift you will pass on to all your descendants.