That opening gave me a pause too. Doesn't Pandas target only structured (tabular) in-core datasets? (Unless you use something like Blaze / Dask / Ray on top.)

That opening gave me a pause too. Doesn't Pandas target only structured (tabular) in-core datasets? (Unless you use something like Blaze / Dask / Ray on top.) Does anyone really work with Pandas on "100's of terabytes of biological data"?