I've also worked with quite a few startups and usually recommend the following: - Python / Node.js for the backend - React.js (with Redux) / Angular for the f

I've also worked with quite a few startups and usually recommend the following: - Python / Node.js for the backend - React.js (with Redux) / Angular for the front-end - MySQL / Postgresql as the db - Host on a digitalocean or linode VM - ReactNative (if using React.js) for mobile apps, prefer to write native apps otherwise. All of the above are proven technologies with Node.js giving an edge when it comes to real-time applications. The hardest part I've found is in having a consistent design, marketing and branding strategy. Usually the inhouse designers are swamped and it gets really tricky for frontend developers to make the beautiful looking widgets that were designed in Adobe InDesign or whatever...