In many primitive cultures certain chemicals were used. "modern" society has many subcultures that still continue to do so however. Eg https://qualiacomputing.

In many primitive cultures certain chemicals were used. "modern" society has many subcultures that still continue to do so however. Eg https://qualiacomputing.com/2016/12/12/the-hyperbolic-geometry-of-dmt-experiences/amp/ https://qualiacomputing.com/2016/12/12/the-hyperbolic-geomet... Caffeine/tobacco are some modern less "powerful" ones.