3 ms·
There's no mention of IVF/in-vitro-fertilization techniques and whether male micro-RNA can survive that process. There apparently are side effects of IVF and I
by nwatson 9y ago
There's no mention of IVF/in-vitro-fertilization techniques and whether male micro-RNA can survive that process. There apparently are side effects of IVF and I wonder whether they could be due to degradation of male RNA transport.
- DrAwdeOccarim 9y agoIf you do ICSI with sperm taken directly from the testis, which is quite common, then the sperm never travel through the epididymis and therefore are not loaded with the microRNAs. So yes, you would certainly have removed the (is life good or shitty) signal that the sperm normally would carry with them. The Rando lab at UMass does a lot of this kind of research if you want to go down the rabbit hole...https://umassmed.edu/randolab/ https://umassmed.edu/randolab/
- klmr 9y agoIt’s not mentioned because it hasn’t been studied yet. That said, side-effects from IVF can be explained much easier, no need to invoke degrading sperm RNA (which is almost certainly not required for healthy fertilisation, and rather a side-effect): IVF is a fairly disruptive and stressful procedure for cells: Among other things, it requires processing cells outside of their natural protective environment. Even though it’s a routine procedure, there’s a high failure rate (which is why multiple oocytes are collected and fertilised, and subsequently the best embryo is picked for implantation).