Yeah, certainly true. I wish I had summarized more of Gwern's take, because he goes into piracetam + choline as a specific example. His take is that it doesn't

Yeah, certainly true. I wish I had summarized more of Gwern's take, because he goes into piracetam + choline as a specific example. His take is that it doesn't violate the rule, but provides a case of a changing environment - burning choline for minor cognitive improvements is a vastly better deal than it was in a choline-scarce environment.