Agree, most public research (In the U.S) is in a poor place as far as "asking the right questions". The amount of under powered and poorly designed studies that

Agree, most public research (In the U.S) is in a poor place as far as "asking the right questions". The amount of under powered and poorly designed studies that get published has driven me to almost ignore research in all but a few journals. The justification (and conclusions) for these studies are delusional at best There is a lot of high quality science, but the signal to noise ration is quickly getting out of hand. Peer review is a busted methodology and i salute place such as arxiv and bioarxiv that seek to disrupt the old paradigms