37signals are in Chicago (and until around 1½ year ago one of them was in Denmark), and Skype was done in Estonia. There are many other stories of successful co

37signals are in Chicago (and until around 1½ year ago one of them was in Denmark), and Skype was done in Estonia. There are many other stories of successful companies that aren't in the major hubs. So I would say that it is definitely possible. Especially now where almost all business can be taken care of over the web. A designer I know even moved to Thailand, and did his work from the beach without skipping a beat - without his customers knowing about it.