4 ms·
I was under the impression that past heavy (ab)users of opioids no longer get any analgesic benefit from them?
by danieltillett 9y ago
I was under the impression that past heavy (ab)users of opioids no longer get any analgesic benefit from them?
- Blindedwino 9y agoYes, I had a friend who was an ex heroin addict, she needed huge quantities of any sort of painkillers to get any effect.
- epmaybe 9y agoIt goes back to basically any medication that acts on G Protein Coupled Receptors (of which opioid Receptors fall under). If given the same dose for over 10 days, by day 3 you are seeing a significant loss of analgesic effect.
- freedomben 9y agoIt depends on how long in the past things were. Over time the body gets closer and closer to "normal."