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Fulltext: https://www.dropbox.com/s/cbpt3bw8ql310kr/2018-gardner.pdf?dl=0 https://www.dropbox.com/s/cbpt3bw8ql310kr/2018-gardner.pdf?d... Worth noting that the
by gwern 9y ago
Fulltext: https://www.dropbox.com/s/cbpt3bw8ql310kr/2018-gardner.pdf?dl=0 https://www.dropbox.com/s/cbpt3bw8ql310kr/2018-gardner.pdf?d...
Worth noting that the genetics here was just 3 SNPs based on a 2010 candidate-gene study of apparently n=133 (it was never published, it's just a conference talk, based on the citation & description of the work in https://www.wsj.com/articles/SB10001424052748703862704575099742545274032 https://www.wsj.com/articles/SB10001424052748703862704575099... ), which made the absolutely crazy claim that "those with a genetic predisposition to benefit from a low-carbohydrate diet lost 2 1/2 times as much weight as those on the same diet without the predisposition". So unfortunately, their total failure is exactly what you would predict from a non-GWAS-derived set of SNPs and the result is meaningless. This tells you nothing about whether SNPs can predict or cause more/less weight loss, be used to optimize diet choice, or have any cross-racial differences, despite people apparently interpreting it that way.
- jobu 9y agoThe key thing for these diets is the ratios of Carb/Fat/Protien : In the HLF vs HLC diets, respectively, the mean 12-month macronutrient distributions were 48% vs 30% for carbohydrates, 29% vs 45% for fat, and 21% vs 23% for protein. Both of those diets seem fairly balanced. A typical ketogenic diet (high-fat, low-carb) is usually < 10% calories from carbohydrates, 20-30% from protein (depending on exercise) and 60-75% fat calories. It seems unlikely any of the HLC participants would have gotten into ketosis, so I don't see this study as being relevant to the current debate over the efficacy of ketogenic diets.