The main non-theoretical concern over such chimeras is that they could host disease variants and transmit them to humans. You don’t want to catch foot & month

The main non-theoretical concern over such chimeras is that they could host disease variants and transmit them to humans. You don’t want to catch foot & month disease. They typically should not leave sterile conditions because of that potential threat. Therefore, having cell-bundles grown in petri dishes and vats is probably preferable than an autonomous live animal. That takes off a bit of the moral conundrum of having cute animals raised to be sacrificed. Vegetarianism and veganism are getting traction fast, so that could become more controversial. SciFi has explored the possibility of having conscious humans raised for their organs, so you could see an increased awareness in the next decades.