What makes macrophages the "most primitive part of the immune system"? How about antimicrobial peptides, which are simpler and evolved earlier? https://en.wiki

What makes macrophages the "most primitive part of the immune system"? How about antimicrobial peptides, which are simpler and evolved earlier? https://en.wikipedia.org/wiki/Antimicrobial_peptides https://en.wikipedia.org/wiki/Antimicrobial_peptides