3 ms·
> You can likely get an antidepressant effect out of Esketamine in the same way that you can get an antidepressant effect out of psychdelics like LSD-25 & Psilo
by ShabbosGoy 9y ago
> You can likely get an antidepressant effect out of Esketamine in the same way that you can get an antidepressant effect out of psychdelics like LSD-25 & Psilocin.
LSD-25 and Psilocin simply amplify your emotional state at a given time, because they act on 5HT receptors. That’s not what an anti-depressant does. In fact, anti-depressants help one regulate emotions correctly. In that sense, Esketamine is truly novel for being a rapid anti-depressant, because it acts as a NMDA antagonist.
- sigotirandolas 9y agoPsychedelics are not simply dumb emotional amplifiers as you characterize them, they can radically alter your mood (for the better or the worse) pretty radically from your initial mood. They can generate or amplify one small insight into a wonderful state of mind, or they can generate or amplify an absurd fear to the point that you lose all sense of hope and reality.
- ShabbosGoy 9y agoCorrect, but that happens to you every day on a minor level. You just don’t notice it because there are filters in your brain. Psychedelics remove those filters. It comes down to inhibitory control. People suffering from depression lack inhibitory control of negative thoughts and emotions, which leads to a feedback loop of thinking more negative thoughts and feeling more negative emotions.
- opportune 9y agoThey also tend to cause permanent personality changes (increasing "openness to experience")