Esketamine[0] works as a NMDA antagonist. Most nootropic drugs, and anti-AD drugs have some interaction with AMPA, NMDA, and glutamate. I have a hunch that mos

Esketamine[0] works as a NMDA antagonist. Most nootropic drugs, and anti-AD drugs have some interaction with AMPA, NMDA, and glutamate. I have a hunch that most mental illnesses have to do with a dysfunctional glutaminergic system, with some misbehaving AMPA/NMDA signaling thrown in there for good measure. [0] https://en.m.wikipedia.org/wiki/Esketamine https://en.m.wikipedia.org/wiki/Esketamine