I've dealt with RSI too, so I have a few years experience trying to minimize mouse use. Other people have talked about the main keyboard shortcuts -- Command-T

I've dealt with RSI too, so I have a few years experience trying to minimize mouse use. Other people have talked about the main keyboard shortcuts -- Command-Tab, Command-Tilde, and Control-F2. Make these second nature. Also, of course, learn the keyboard commands for your most-used applications. You can add and change many keyboard shortcuts in the Keyboard preferences pane in System Preferences. Make liberal use of this to make the commands you use most often the easiest to remember and invoke. I used Quicksilver devotedly for years, but it became much less stable with Snow Leopard. It may be better now that it's under more active open-source development, but I'm happy with LaunchBar. Certainly one of those two (or Butler, or Alfred, or there's probably others) will allow you to perform basic filesystem tasks (launching, opening, moving, copying, duplicating, opening a document with a specific application, etc. etc.) with a few quick key commands. A general suggestion: Don't try to learn every single keyboard shortcut all at once -- it'll never work. Instead, figure out the single most common reason you're reaching for the mouse, and replace that with a keyboard method. Once that's second nature, repeat the process. You'll be surprised at how quickly you can learn this way. Use shell scripting, AppleScript, Automator, Keyboard Maestro, and/or Hazel to simplify anything you do repeatedly. Once you've reduced mouse use, you can use these tools to reduce keyboard use as well! Good luck.