Tweeten (a Tweetdeck clone) is my preferred one, but other people like Tweetbot, and Twitteriffic just kickstarted a new Mac app that people seem to like too.

Tweeten (a Tweetdeck clone) is my preferred one, but other people like Tweetbot, and Twitteriffic just kickstarted a new Mac app that people seem to like too. (typing that sentence out made me realize just how ridiculous Twitter app names really are :-) )