3 ms·
If by trained model you mean PGS, yes, it would be trivial. While the fitting of the optimal weights may be computationally intensive, it's still just a simple
by gwern 9y ago
If by trained model you mean PGS, yes, it would be trivial. While the fitting of the optimal weights may be computationally intensive, it's still just a simple little linear model: look up the SNP value, add or subtract a small coefficient for each of the 30k or whatever 'activated' SNPs, and get the net total.