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Coordinate descent is simple but the resource requirements may complicate your implementation running over n=500k with tens of thousands of markers each; as it
by gwern 9y ago
Coordinate descent is simple but the resource requirements may complicate your implementation running over n=500k with tens of thousands of markers each; as it was described to me, they were using a workstation with like 128GB RAM... (Plus of course you need access to the UKBB dataset in the first place.)
- moyix 9y agoThat's to replicate the study; presumably if the authors released their trained model it would be much less computationally expensive to run it on your own data?
- gwern 9y agoIf by trained model you mean PGS, yes, it would be trivial. While the fitting of the optimal weights may be computationally intensive, it's still just a simple little linear model: look up the SNP value, add or subtract a small coefficient for each of the 30k or whatever 'activated' SNPs, and get the net total.