The size of the implant can't be the issue because the implants (empty) were also implanted in the active controls, who maintained their weight/food intake. Any

The size of the implant can't be the issue because the implants (empty) were also implanted in the active controls, who maintained their weight/food intake. Any discomfort must have come from the additional weight, but of course, that ought to also be true of mice who are fat. The crosscheck with the less-boney mice, without any implants at all, also helps support that it is the change in weight itself and not an associated effect of the implanted spheres, which is the cause. > Could they do this again with a larger animal with weights that could be applied without any potential discomfort? One hopes so. Larger animals are harder to work with, of course. But it's wild to imagine that putting on a weight vest might help you lose weight, even for a field which has no shortage of strange results relating to genetics/diet/metabolism/weightloss once you go beyond theological doctrine like CICO.