> GWAS have proven to be, at best, of little value. In fact, due to the unfortunate way that many researchers chase p-values, these analyses often result in mis

> GWAS have proven to be, at best, of little value. In fact, due to the unfortunate way that many researchers chase p-values, these analyses often result in misdirection. I would certainly challenge that, its just that some people considered GWAS as the solution for everything which it clearly isn't, especially because rare mutations where underestimated (and cannot be discriminated in GWAS) and because GWAS was never able to detect the causing variant, just associated/linked genomic loci. And last but not least, the regulatory genome is turning out more and more complex (with interacting variants leading to complexities of O(x^n)) and we do not know yet how it will all be understood, its just that GWAS is one of the better tools we have.