Have you checked out scikit-allel? It is fairly comprehensive in terms of calculating basic population stats, and the developer is highly active. scikit-allel:

Have you checked out scikit-allel? It is fairly comprehensive in terms of calculating basic population stats, and the developer is highly active. scikit-allel: http://scikit-allel.readthedocs.io/en/latest/index.html http://scikit-allel.readthedocs.io/en/latest/index.html scikit-allel example: http://alimanfoo.github.io/2015/09/21/estimating-fst.html http://alimanfoo.github.io/2015/09/21/estimating-fst.html zarr: https://github.com/zarr-developers/zarr https://github.com/zarr-developers/zarr